The Role of Dock8 in T Cell Polarity and Function

Grant number: 1079318 | Funding period: 2015 - 2018

Completed

Abstract

Specialised immune cells, called cytotoxic T cells, circulate through the body, and kill infected cells to protect us from disease. We discovered that a protein, DOCK8, is important for the regulation of T cell function. Importantly, humans with mutations in the DOCK8 gene suffer from a debilitating, and potentially lethal, immunodeficiency disease. This project will therefore elucidate the role of DOCK8 in immune cells, to better understand the consequences of DOCK8 deficiency for immunity.

Related publications (2)

Protection from EAE in DOCK8 mutant mice occurs despite increased Th17 cell frequencies in the periphery

AS Wilson, HD Law, CB Knobbe-Thomsen, CJ Kearney, J Oliaro, C Binsfeld, G Burgio, L Starrs, D Brenner, KL Randall, A Brüstle

2019-05-01

Mutation of Dedicator of cytokinesis 8 (DOCK8) has previously been reported to provide resistance to the Th17 cell dependent EAE i..

DOCK8 drives Src-dependent NK Cell effector function

CJ Kearney, SJ Vervoort, KM Ramsbottom, AJ Freeman, J Michie, J Peake, JL Casanova, C Picard, SG Tangye, CS Ma, RW Johnstone, KL Randall, J Oliaro

2017-09-15

Mutations in the dedicator of cytokinesis 8 (DOCK8) gene cause an autosomal recessive form of hyper-IgE syndrome, characterized by..

University of Melbourne Researchers

Jane Oliaro